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Trade name:REQUIP
Specifications:0.5mg ；3mg (calculated as C16H24N2O)
Dosage form:tablet
* Please be kindly noted products are supplied for RLD supplies/ Reference listed drugs/ Comparator Drug Clinical trials. We do not sell to patients.
| Name | Ropinirole Hydrochloride Tablets |
|---|---|
| Trade name | REQUIP |
| Specifications | 0.5mg ；3mg (calculated as C16H24N2O) |
| Dosage form | tablet |
| Licensee | GLAXO SMITHKLINE LLC |
| Remarks | American Orange Book |
| Category | Reference Listed Drugs (RLDs) |
Ropinirole hydrochloride tablets are anti-Parkinson's disease drugs. Used in combination with levodopa to treat the symptoms and signs of primary Parkinson's disease.
Ropinirole is a non-ergoline-structured dopamine receptor agonist, with high relative specificity in vitro, with complete intrinsic activity for D2 and D3 dopamine receptor subtypes, and high affinity for binding to D3 receptor subtypes In D2 or D4 receptor subtypes.
Ropinirole has a moderate affinity for opioid receptors in vitro. The affinity of ropinirole and its metabolites to dopamine receptors D1, 5-HT1, 5-HT2, benzodiazepines, GABA, muscarinic, α1-, α2-, and β-adrenergic receptors in vitro can be ignored.
The exact mechanism of action of ropinirole in the treatment of Parkinson's disease is not yet known, but it is believed to be due to the stimulation of the postsynaptic dopamine D2 receptor in the caudate putamen of the brain. This conclusion is supported by studies of various animal models of Parkinson's disease, showing that ropinirole can improve motor function. In particular, ropinirole can reduce the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic pathway in the substantia nigra striatum in primates Movement defects caused by damage. The relevance of D3 receptor binding in Parkinson's disease is unclear.
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