The purpose of the treatment of ulcerative colitis is to control the acute attack of ulcerative colitis, promote the healing of the mucosa, maintain the remission of symptoms, reduce the recurrence of the disease, and prevent complications. The main drug to control the inflammatory response is sulfasalazine, followed by Mesalazine. Mesalazine and sulfasalazine are actually pentaaminosalicylic acid preparations, but the price of Mesalazine is higher. Of course, the side effects are less than sulfasalazine. Mesalazine suppositories are suitable for treating lesions Restricted to patients in the workplace.

The second drug is glucocorticoids. Glucocorticoids have a better effect on the acute febrile stage. If the lesion is limited to the rectosigmoid colon, hydrocortisone succinate can be used as a retention enema.

The third category is immunosuppressants. Immunological preparations include salivazopyridine. In the remission period of this disease, the main method of controlling inflammation is pentaaminosalicylic acid, which is sulfasalazine, mesalazine, or olsalazine for treatment.

If the remission in the active phase is induced by immune preparations such as azathioprine, the same dose should be used to maintain it. There is no unified opinion on the course of maintenance treatment. In ulcerative colitis, symptomatic treatment should be carried out to correct the level Electrolyte disorders, anemia patients can receive blood transfusions, etc., and certain education should be given to patients to avoid excessive pressure. A digestible diet should be given during acute activity. Emergency surgery is suitable for complications such as bleeding or perforation.

Mesalazine, sulfasalazine, balsalazine sodium, and olsalazine have different names, but their active ingredients are all 5-aminosalicylic acid, but their chemical structures are different.

Because 5-aminosalicylic acid has a characteristic, that is, it is not resistant to gastric acid. After oral administration, it is quickly absorbed and decomposed in the stomach and small intestine, and loses its activity. When it reaches the colon, it has no medicinal effect and no anti-inflammatory effect.

In order to make 5-aminosalicylic acid reach the colon smoothly and exert its medicinal effect, it is protected by preparation technology, so there are four kinds of drugs with different names.

1. Mesalazine

Features: Mesalazine is 5-aminosalicylic acid. The 5-aminosalicylic acid is protected by making an enteric-coated sustained-release preparation so that the 5-aminosalicylic acid can be released slowly and continuously in the colon to exert an anti-inflammatory effect. Dosage forms include enteric-coated sustained-release granules and enteric-coated sustained-release tablets.

Medication Tips: Sustained-release granules and sustained-release tablets should be swallowed and not chewed.

Notes: Those who are allergic to salicylic acid should not take it.

2. Sulfasalazine

Features: Sulfasalazine is a traditional drug for treating ulcerative colitis. It protects the active ingredient 5-aminosalicylic acid by forming an azo compound with 5-aminosalicylic acid and sulfapyridine. Oral preparations include sulfasalazine enteric-coated tablets and enteric-coated capsules.

Medication tips: This product is an enteric-coated tablet or capsule. Do not break or chew when taking it. The capsule should be intact.

Notes: Because the ingredients contain 5-aminosalicylic acid and sulfapyridine, those who are allergic to these two drugs are contraindicated.

3. Balsalazide Sodium

Features: Balsalazide sodium is the prodrug of 5-aminosalicylic acid, which protects the active ingredient by forming an azo compound from 5-aminosalicylic acid and 4-aminobenzoyl-β-alanine. Dosage forms include tablets, capsules, and granules.

Medication Tips: Disabled for patients allergic to 5-aminosalicylic acid.

4. Osalazine Sodium

Features: Osalazine sodium protects the active ingredient through the formation of two molecules of 5-aminosalicylic acid to form an azo compound. After oral administration, under the action of colonic bacteria, it is decomposed into two molecules of 5-aminosalicylic acid, which acts on the inflammatory site and exerts anti-inflammatory effect. Dosage forms are capsules.