Allopurinol and its metabolites can inhibit xanthine oxidase, so that hypoxanthine and xanthine cannot be converted into uric acid, that is, the synthesis of uric acid is reduced, thereby reducing the concentration of uric acid in the blood, and reducing the deposition of urate in bones, joints and kidneys. Drugs that inhibit the synthesis of uric acid. This product can inhibit the activity of liver drug enzymes.

　　1、 Physical and chemical properties

　　Allopurinol is a white crystalline powder. It is almost insoluble in water, ethanol or chloroform. Easily soluble in sodium hydroxide solution.

　　2、chemical properties

　　White or off-white crystalline powder; almost odorless. Very slightly soluble in water or ethanol. Insoluble in chloroform or ether; soluble in sodium hydroxide or potassium hydroxide.

　　3、 indications

　　1) Primary and secondary hyperuricemia, especially hyperuricemia caused by excessive uric acid production.

　　2) Recurrent or chronic gout;

　　3) Uric acid kidney stones and/or uric acid nephropathy;

　　4) Hyperuricemia with renal insufficiency.

　　4、Pharmacological effects and mechanism of action

　　Allopurinol and its metabolite oxypurinol inhibit the activity of xanthine oxidase (the latter can convert hypoxanthine into xanthine, and then xanthine into uric acid) Chemicalbook, which reduces the production of uric acid, blood and urine The content of uric acid in it is reduced to a level below the solubility, thereby preventing the deposition of uric acid stones and helping to re-dissolve gout nodules and uric acid crystals.

　　5、 Product advantages

　　Allopurinol was approved by the FDA for marketing in the United States in 1982 and approved by the National Medical Products Administration in 1999. It is a uric acid-lowering drug. The number of patients with hyperuricemia and gout is increasing year by year. There are currently many uric acid-lowering drugs. Among them, allopurinol can effectively inhibit the production of uric acid and is low in price. It has become a widely used drug for patients with hyperuricemia and gout, and is considered the only drug. Drugs that inhibit the synthesis of uric acid. The drug is an isomer of hypoxanthine and an inhibitor of xanthine oxidase (XO). It has been the main medicine for the treatment of gout. With the continuous expansion of the theory of oxygen free radicals, the research on the antioxidant effect of allopurinol has also increased. In addition to reducing the synthesis of uric acid to treat gout, the drug can also reduce the generation of oxygen free radicals in ischemia-reperfusion injury, thereby reducing oxygen free radicals in the body (cardiovascular, brain, lung, gastrointestinal, liver, etc.) ) Damage. In addition, it also has the effect of expanding the tube to provide a new method for the treatment of chronic heart failure. National Medical Insurance List of drugs; EU & U.S. & Japan listed drugs;

　　6、 Where can I purchase allopurinol

　　This reference product and standard product are provided by TOSUN PHARM website inquiry procurement service

　　If you want to purchase or learn more about allopurinol, you can click on the online consultation to contact us and look forward to your cooperation.