The results of mouse fertility and general reproductive toxicity tests suggested that cetirizine had no harm to fertility when administered orally at a dose of 64mg/kg(equivalent to about 25 times the maximum recommended daily oral dose for adults in terms of body surface area). No teratogenic effect was observed in mice, rats, and rabbits with oral doses of 96, 225, and 135mg/kg (equivalent to 40, 180, and 220 times of the maximum daily oral dose clinically recommended for adults, respectively, based on body surface area). However, there are not yet sufficient and strictly controlled clinical research data on pregnant women. Because animal reproduction studies do not always predict the effects of drugs on humans, it should only be taken during pregnancy if it is really needed. When the oral dose of lactating mice (female mice) was up to 96mg/Kg(translated according to body surface area, about 40 th of the recommended maximum daily oral dose for adults), the body growth of Suckling mice was delayed. Beagler dog studies have shown that about 3 percent of the amount of paeony is excreted through milk.