Methenamine Hippurate Tablets Reference Listed Drug

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Name	Methenamine Hippurate Tablets
Trade name	HIPREX
Specifications	1g
Dosage form	tablet
Licensee	US PHARMACEUTICAL HOLDINGS II LLC
Remarks	American orange paper

This product is a preventive medication for lower urinary tract infections, and is suitable for patients with indwelling catheters after urinary tract surgery and cystoscopy. The antibacterial effect of this product itself is not strong, but after entering the body, it can be hydrolyzed into hippuric acid and formaldehyde under the condition of acidic urine (pH about 6.5). Formaldehyde can denature pathogen proteins and exert non-specific antibacterial effects. The concentration of formaldehyde in urine varies according to pH value, urine volume and excretion rate, and it has a sterilization or antibacterial effect. Hippuric acid can maintain the acidity of urine and promote the release of formaldehyde. Almost all bacteria and fungi are sensitive to the non-specific antibacterial effect of formaldehyde produced by the hydrolysis of this product.

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