Probucol Tablets Reference Listed Drug

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Name	Probucol Tablets
Trade name	Lorelco
Specifications	0.25g
Dosage form	tablet
Licensee	Otsuka Pharmaceutical Co., Ltd.
Remarks	American Orange Book

This product has the effects of regulating blood lipids and anti-lipid peroxidation. 1. Blood lipid regulation effect: This product reduces blood cholesterol and low-density lipoprotein by reducing cholesterol synthesis and promoting cholesterol decomposition; by changing the nature and function of high-density lipoprotein subtypes, it affects lecithin cholesterol acyltransferase and cholesterol lipid transfer The function of protein and apolipoprotein E, to restore the lipidated cholesterol/total cholesterol ratio to normal, etc., enhance the reverse transport of blood high-density lipoprotein cholesterol; by inhibiting the expression of intercellular adhesion factor-1 and P-selectin Inhibits the adhesion of monocytes to endothelial cells. Therefore, this product can prevent atherosclerosis and the cardiovascular and cerebrovascular diseases caused by it. 2. Anti-lipid peroxidation effect: This product has a significant anti-lipid peroxidation effect, which can inhibit the gene expression of inflammatory factors and atherogenic factors and free radical-mediated inflammation, improve endothelial relaxation function, thereby Inhibit the formation and regression of foam cells and atherosclerotic plaques or reduce atherosclerotic plaques. Therefore, this product can resist restenosis after angioplasty and has the effect of reducing xanthomas.

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