Riluzole Tablets Reference Listed Drug

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Name	Riluzole Tablets
Trade name	RILUTEK
Specifications	50mg
Dosage form	tablet
Licensee	Aventis Pharma S.A.
Remarks	Original research import

The mechanism of riluzole is still unclear, and its effect may be related to the inhibition of glutamate release, stabilizing the inactivation state of voltage-dependent sodium channels, and interfering with intracellular events after neurotransmitter binding to excitatory amino acid receptors. An animal experiment showed that riluzole can prolong the survival time of ALS transgenic animal models. In addition, studies on various animal models of nerve excitability injury have shown that riluzole has neuroprotective effects. In vitro studies have shown that riluzole can protect cultured rat motor neurons from the excitotoxic damage of glutamate and inhibit the death of cortical cells caused by hypoxia.

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