Sertraline Hydrochloride Tablets Reference Listed Drug

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Name	Sertraline Hydrochloride Tablets
Trade name	ZOLOFT
Specifications	25mg (calculated as C17H17Cl2N)；50mg (calculated as C17H17Cl2N)
Dosage form	tablet
Licensee	PFIZER PHARMACEUTICALS INC
Remarks	American Orange Book

Sertraline hydrochloride is a selective serotonin reuptake inhibitor, and its mechanism of action is related to its inhibition of central neuron serotonin reuptake. At clinical doses, sertraline blocks the uptake of serotonin by human platelets. Research suggests that sertraline is a potent and selective neuronal serotonin reuptake inhibitor, with only a weak effect on norepinephrine and dopamine. In vitro studies have shown that sertraline has effects on adrenergic receptors (α1, α2, β), cholinergic receptors, GABA receptors, dopaminergic receptors, histamine receptors, serotoninergic receptors (5HT1A, 5HT1B, 5HT2) or benzodiazepine receptors have no obvious affinity. The antagonistic effect on the above-mentioned receptors is considered to be related to the sedative effect, anticholinergic effect and cardiotoxicity of other psychiatric drugs. Long-term administration of sertraline to animals can down-regulate norepinephrine receptors in the brain, which is consistent with the effects of other clinical antidepressants. Sertraline has no inhibitory effect on monoamine oxidase.

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