Oxycodone Hydrochloride Tablets Reference Listed Drug

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Name	Oxycodone Hydrochloride Tablets
Trade name	ROXICODONE
Specifications	5mg
Dosage form	tablet
Licensee	MALLINCKRODT INC
Remarks	American Orange Book

Oxycodone hydrochloride is an opioid analgesic, a pure opioid receptor agonist, and its main therapeutic effect is analgesia. Like all other pure opioid receptor agonists, oxycodone increases its analgesic effect with increasing doses, while mixed opioid receptor agonists/antagonists or non-opioid analgesics only increase its analgesic effect with increasing doses To a limited extent. For pure opioid receptor agonist analgesics, there is no definite maximum dose; the maximum analgesic effect can only be determined by side effects, and more serious side effects may include drowsiness and respiratory depression. 2. The exact mechanism of the analgesic effect of oxycodone is unclear. Some specific CNS opioid receptors with opioid endogenous substances were found in the brain and spinal cord, which may be related to the analgesic effect of oxycodone. 3. Oxycodone produces respiratory depression by directly acting on the respiratory center of the brainstem, including reduced responsiveness to carbon dioxide and electrical stimulation. Oxycodone directly acts on the cough center and inhibits the cough reflex. It may have an antitussive effect at lower doses than conventional labor pains. Oxycodone can cause pupils to shrink, even in a completely dark environment. In the case of an overdose of oxycodone, there may be significant pupil dilation rather than pupil dilation.

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