Milnacipran Hydrochloride Tablets Reference Listed Drug

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Name	Milnacipran Hydrochloride Tablets
Trade name	Toledomin
Specifications	25mg (calculated as C15H22N2O•HCl)
Dosage form	tablet
Licensee	Asahi Kasei Pharma Co., Ltd.
Remarks	Japanese Orange Book

Milnacipran hydrochloride is an antidepressant and a specific 5-HT and NE reintake inhibitor. Milnacipran hydrochloride has affinity for the reuptake sites of 5-HT and NE in the rat brain, inhibits the reuptake of 5-HT and NE, and increases the extracellular 5-HT and NE concentrations in the rat brain. Milnacipran hydrochloride has no effect on the receptors and 5-HT2 receptors in the rat brain. Animal test results show that milnacipran hydrochloride can shorten the ""immobility"" time of the forced swimming test in mice and rats, inhibit the ""stuck"" behavior of the conditioned fear stress response test in rats in a dose-dependent manner, and antagonize the induction of reserpine The body temperature of the rat drops.

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