Doxycycline Hyclate Tablets Reference Listed Drug

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Name	Doxycycline Hyclate Tablets
Trade name	Vibramycin
Specifications	50mg；100mg  (according to C22H24N2O8)
Dosage form	tablet
Licensee	Pfizer Japan Inc.
Remarks	Japanese Orange Book

This product can be used for the following diseases: 

(1) Rickettsiosis, such as epidemic typhus, endemic typhus, Rocky Mountain fever, tsutsugamushi and Q fever. 

(2) Mycoplasma infection. 

(3) Chlamydia infections, including psittacosis, venereal disease, lymphoma, non-specific urethritis, salpingitis, cervicitis and trachoma. 

(4) Regression fever. 

(5) Brucellosis. 

(6) Cholera. 

(7) Tularemia. 

(8) Plague.

 (9) Chancroid. 

The treatment of brucellosis and plague needs to be combined with aminoglycosides. Because the current common pathogenic bacteria are severely resistant to tetracyclines, indications for application are only available when the pathogens are sensitive to this product. Most Staphylococci are resistant to this product. This product can be used for tetanus, gas gangrene, yaws, syphilis, gonorrhea, leptospirosis, and infections of Actinomyces and Listeria in patients allergic to penicillins. It can be used as an adjuvant treatment for patients with moderate and severe acne.

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