Risperidone Tablets Reference Listed Drug

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Name	Risperidone Tablets
Trade name	Risperdal
Specifications	1mg，2mg，3mg
Dosage form	tablet
Licensee	Janssen Pharmaceuticals Inc
Remarks	American Orange Book

【Indications】

 It is used to treat acute and chronic schizophrenia and various other psychotic states with obvious positive symptoms (such as hallucinations, delusions, thinking disorders, hostility, suspicion) and obvious negative symptoms (such as unresponsiveness, apathy, and social Indifferent, less language). It can also reduce the emotional symptoms related to schizophrenia (such as depression, guilt, anxiety). For patients with effective treatment in the acute phase, this product can continue to exert its clinical efficacy in the maintenance phase. 

【Pharmacology】

 Risperidone/is a selective monoamine antagonist with high affinity for 5HT2 receptors, D2 receptors, α1 and α2 receptors and H1 receptors. It also has an antagonistic effect on other receptors, but it is weak. It has low to moderate affinity to 5HT1C, 5HT1 D and 5HT1A, weak to D1 and haloperidol-sensitive α receptors, and has no affinity to M receptors or β1 and β2 receptors. The mechanism of risperidone in the treatment of schizophrenia is unclear. It is believed that its therapeutic effect is the result of a combined effect on D2 receptor and 5HT2 receptor antagonism. The antagonism of receptors other than D2 and 5HT2 may be related to other effects of risperidone.

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