(E)-Thiothixene

(E)-Thiothixene (100 mg)

USP Catalog No:1666006

CAS 3313-27-7

Molecular Formula:C23H29N3O2S2

Product Type:Reference Standard

Thiothixene is a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.

N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-2-thioxanthenesulfonamide is a member of thioxanthenes.

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

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