Crizotinib Capsules Reference Listed Drug

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Name	Crizotinib Capsules
Trade name	XALKORI
Specifications	0.2g；0.25g
Dosage form	Capsules
Licensee	Pfizer Ltd.
Remarks	Original research import

Crizotinib capsules are anti-tumor drugs. It is used for the treatment of patients with local late stage or metastatic non-small cell lung cancer (NSCLC) who are positive for anaplastic lymphoma kinase (ALK) determined by the CFDA-approved test method. Crizotinib is an inhibitor of iliac acid receptors, including ALK, hepatocyte growth factor receptor (HGFR, c-Met), ROS1 (c-cos) and RON. The translocation can promote the ALK gene to cause the expression of oncogenic fusion proteins. The formation of ALK fusion protein can cause the activation and deregulation of gene expression and signal, which in turn promotes the proliferation and survival of tumor cells expressing these proteins. Crizotinib has a concentration-dependent inhibitory effect on the phosphorylation of ALK, ROS1 and c-Met detected at the cellular level in tumor cell lines, and it has a concentration-dependent inhibitory effect on xenografts expressing EML4-ALK or NPM-ALK fusion protein or c-Met. Tumor mice have anti-tumor activity.

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