Levetiracetam Tablets Reference Listed Drug

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Name	Levetiracetam Tablets
Trade name	Keppra
Specifications	0.25g；0.5g
Dosage form	tablet
Licensee	UCB Pharma S.A.
Remarks	Original research import

Levetiracetam is a pyrrolidone derivative, and its chemical structure is not related to existing anti-seizure drugs. The exact mechanism of the anti-seizure effect of levetiracetam is still unclear. The antiepileptic effect of levetiracetam has been evaluated in various animal models of epilepsy. Levetiracetam has no inhibitory effect on simple epileptic seizures induced by the maximum stimulation of electric current or multiple convulsants, and shows only weak activity in the submaximum stimulation and threshold test. However, protective effects have been observed for pilocarpine and kainic acid-induced focal seizures secondary to generalized seizures. These two chemical convulsants can mimic the complex partial seizures of some people with secondary generalized seizures. characteristic. Levetiracetam has an inhibitory effect on the kindling process and kindling state of the rat kindling model with complex partial seizures. The predictive value of these animal models for specific types of epilepsy in humans is still unclear. In vivo and in vitro tests have shown that levetiracetam inhibits epileptiform bursts in the hippocampus, but has no effect on the excitability of normal neurons, suggesting that levetiracetam may selectively inhibit the hypersynchrony and epileptiform bursts of epileptiform discharges. The spread of pain episodes. Levetiracetam has no affinity for many known receptors at concentrations as high as 10μM, such as benzodiazepines, GABA, glycine, NMDA, reuptake sites and second messenger systems. In vitro experiments showed that levetiracetam had no effect on neuronal voltage-gated sodium channels or T-type calcium currents. Levetiracetam does not directly facilitate GABAergic neurotransmission, but studies have shown that it has an antagonistic effect on the activities of the negative regulators of GABA and glycine-gated current in cultured neurons. Studies have found that there is a neuronal binding site for levetiracetam in rat brain tissue, and it has saturability and stereoselectivity; however, the binding site has not been identified and its function is unclear.

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