Mecobalamin Tablets Reference Listed Drug

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Name	Mecobalamin   Tablets
Trade name	Methycobal
Specifications	0.5mg
Dosage form	tablet
Licensee	Eisai Co., Ltd.
Remarks	Japanese Orange Book

This product is an endogenous coenzyme B12, which participates in the cycle of one carbon unit and plays an important role in the transmethylation reaction of synthesizing methionine from homocysteine. Animal experiments have found that this product is easier to enter neuronal organelles than cyanocobalamin, participates in the synthesis of thymidine in brain cells and spinal cord neurons, promotes the utilization of folic acid and nucleic acid metabolism, and promotes nucleic acid and protein synthesis more than cyanocobalamin. This product can promote axon transport function and axon regeneration, normalize the transport of sciatic nerve axon skeleton protein in streptozotocin-induced diabetic rats, and inhibit neurodegeneration caused by drugs, such as adriamycin, propylene Nerve degeneration caused by amide and vincristine and neurological diseases in spontaneously hypertensive rats. It was found in rat tissue culture that this product can promote lecithin synthesis and neuronal myelination. This product can restore the delayed nerve synapse transmission and neurotransmitter reduction to normal, and restore the endplate potential induction by improving the excitability of nerve fibers, and can restore the acetylcholine in the brain of rats fed with choline deficiency to normal levels.

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