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Trade name:LESCOL
Specifications:20mg (according to C24H25FNO4)；40mg (calculated as C24H25FNO4)
Dosage form:Capsules
* Please be kindly noted products are supplied for RLD supplies/ Reference listed drugs/ Comparator Drug Clinical trials. We do not sell to patients.
| Name | Fluvastatin Sodium Capsules |
|---|---|
| Trade name | LESCOL |
| Specifications | 20mg (according to C24H25FNO4)；40mg (calculated as C24H25FNO4) |
| Dosage form | Capsules |
| Licensee | NOVARTIS FARMACÉUTICA, S.A. |
| Remarks | Listed in EU (Origin: Spain) |
| Category | Reference Listed Drugs |
This product is a fully synthetic cholesterol-lowering drug and is a hydroxymethylglutaryl coenzyme A (HMG-Coenzyme A) reductase inhibitor. HMG-pase A can be converted to 3-methyl-3,5-dihydroxyvalerate. The action site of this product is in the liver, it can inhibit the synthesis of endogenous cholesterol, reduce the cholesterol content in liver cells, stimulate the synthesis of low-density lipoprotein (LDL) receptors, increase the uptake of LDL particles, and reduce the concentration of plasma total cholesterol. effect. According to the literature, men and women aged 35-75 years with mild-to-moderate hypercholesterolemia (baseline LDL-C 115-190mg/dl, or 3.0-4.9mmol/l) and coronary heart disease (CHD) For female patients, quantitative coronary angiography was used for the study of coronary atherosclerosis. This is a randomized, double-blind, placebo-controlled clinical study. 429 patients were given fluvastatin 20 mg twice daily or placebo in addition to standard treatment. Angiography was performed at baseline and at two and a half years for evaluation. Based on changes in the anterior and posterior smallest lumen diameter (MLD, primary endpoint), stenosis percentage, or the formation of new lesions in each patient, fluvastatin sodium significantly slowed the progression of coronary artery disease.
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