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Reference Listed Drugs
Tramadol Hydrochloride Capsules Reference Listed Drug

Tramadol Hydrochloride Capsules Reference Listed Drug

Trade name:Tramal
Specifications:50mg
Dosage form:Capsules

Product Details

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Name Tramadol  Hydrochloride Capsules
Trade name Tramal
Specifications 50mg
Dosage form Capsules
Licensee Grunenthal GmbH
Remarks Original research import



This product is a non-opioid central analgesic. Although it can also bind to opioid receptors, its affinity is very weak. Its affinity for μ receptors is equivalent to 1/6000 of morphine, and its affinity for κ and δ receptors is only It is 1/25 of μ receptor. Tramadol is a racemate, its (+) enantiomer acts on opioid receptors, while (-) enantiomer inhibits the reuptake of norepinephrine at neuronal synapses and increases extraneuronal 5- Serotonin concentration. Thereby affecting the transmission of pain and producing analgesic effect, the intensity of which is 1/8–1/10 that of morphine. This product has no respiration inhibitory effect and has little dependence on long-term application. It has antitussive effect, the strength is 50% of codeine, and does not affect the release of histamine.

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