Primaquine Phosphate Tablets Reference Listed Drug

* Please be kindly noted products are supplied for RLD supplies/ Reference listed drugs/ Comparator Drug Clinical trials. We do not sell to patients.

Name	Primaquine Phosphate Tablets
Trade name	Primaquine
Specifications	26.3mg (15mg based on primaquine C15H21N3O)
Dosage form	tablet
Licensee	SANOFI AVENTIS US LLC
Remarks	American Orange Book

This product can kill vivax malaria, vivax malaria, falciparum malaria and ovarian malaria strains, especially vivax malaria. It can also kill the gametophytes of various malaria parasites, especially for falciparum malaria. Strong, so that it can not develop in the mosquito body, to block transmission. This product has a weak effect on the worms of the red inner stage. The antimalarial mechanism of primaquine is not fully understood, and it may be related to interference with DNA synthesis. Plasmodium parasites and tissue cells are placed in primaquine solution for 8 hours. The electron microscope observation shows that primaquine can make The morphology of the mitochondria of Plasmodium changed, manifested as mitochondrial swelling and cytoplasmic vacuoles. The drug can inhibit the oxidation of mitochondria and significantly reduce the plasma parasite's oxygen uptake. Primaquine is metabolized in the body and converted into quinoline quinone derivatives with strong oxidizing properties, which can convert reduced glutathione (GSH) in red blood cells into oxidized glutathione (GSSH). When reducing, it needs to consume reduced coenzyme II (NADPH). Since Plasmodium has consumed coenzyme Ⅱ (NADP) in the liver parenchymal cells during the infrared phase, the effect of primaquine interferes with the reduction process of coenzyme Ⅱ, reduces coenzyme Ⅱ, and seriously destroys the sugar metabolism and oxidation process of Plasmodium. .

We are a global professional manufacturer and supplier of reference drug products, featuring high-quality services and competitive prices. You can get the most favorable reference drug prices here. If you need customized services, please contact us immediately.

Hot Tags: Primaquine Phosphate Tablets Reference Listed Drug, China, suppliers, manufacturers, factory, customized, price, pricelist, in stock, Olanzapine Tablets, Acarbose Tablets, Phenytoin Sodium Tablets, Agomelatine Tablets, Bimatoprost Ophthalmic, Adefovir Dipivoxil Tablets

• Previous: Ferrous Sulfate Tablets Reference Listed Drug
• Next: Praziquantel Tablets Reference Listed Drug