Praziquantel Tablets Reference Listed Drug

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Name	Praziquantel Tablets
Trade name	Biltricide
Specifications	600mg
Dosage form	tablet
Licensee	BAYER HEALTHCARE PHARMACEUTICALS INC
Remarks	American Orange Book

This product is effective against schistosomiasis, tapeworm, cysticercosis, clonorchis sinensis, lung fluke and ginger fluke. There are two main pharmacological effects on the parasite: 1. The worm body muscles undergo tonic contraction and produce spastic paralysis. The body tension of Schistosoma worms increases only 20 seconds after exposure to low concentrations of praziquantel, and when the drug concentration reaches 1 mg/L or more, the body contractures immediately. Muscle contraction may be related to the increase of praziquantel's cell membrane permeability and the loss of intracellular calcium ions. 2. Cortex damage of parasites and host immune function participation: Praziquantel has a rapid and obvious damage effect on the cortex of parasites, causing syncytial outer skin swelling, vacuoles, formation of bullae, protruding body surface, and finally epidermal erosion and ulceration , Almost all the secretions disappeared, and the circular muscles and longitudinal muscles also quickly dissolved. In the host, vacuole degeneration of the worm skin can be seen 15 minutes after taking the medicine. After the cortex is destroyed, it affects the body's absorption and excretion function. More importantly, its body surface antigen is exposed, which makes it vulnerable to host immune attack. A large number of eosinophils attach to the skin lesions and invade, prompting the body's death. In addition, praziquantel can also cause secondary changes, depolarize the surface membrane of the worm, and significantly reduce the activity of cortical alkaline phosphatase, resulting in inhibition of glucose uptake and exhaustion of endogenous glycogen. Praziquantel can also inhibit the synthesis of nucleic acid and protein.

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