Axitinib Reference Listed Drug

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Name	Axitinib
Trade name	Inlyta
Specifications	1mg；5mg
Dosage form	tablet
Licensee	Pfizer Limited
Remarks	Original research import

This product is used for adult patients with advanced renal cell carcinoma (RCC) who have previously received a tyrosine kinase inhibitor or cytokine treatment failure. Axitinib can inhibit tyrosine kinase receptors, including vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2 and VEGFR-3) at therapeutic doses. These receptors are associated with pathological angiogenesis, tumor growth, and cancer progression. In vitro experiments and in vivo mouse model experiments show that axitinib can inhibit VEGF-mediated endothelial cell proliferation and survival; in tumor-bearing mouse models, axitinib can inhibit tumor growth and phosphorylation of VEGFR-2.

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