Isosorbide Dinitrate Tablets Reference Listed Drug

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Name	Isosorbide Dinitrate Tablets
Trade name	ISORDIL
Specifications	5mg
Dosage form	tablet
Licensee	VALEANT PHARMACEUTICALS NORTH AMERICA LLC
Remarks	American Orange Book, American listing name: Ergotamine Tartrate and Caffeine Tablets

This product is the main active metabolite of /isosorbide dinitrate. Like other organic nitrates, isosorbide mononitrate releases nitric oxide. Nitric oxide increases cGMP by activating guanylate cyclase, activates cGMP-dependent protein kinases, and changes various proteins in smooth muscle cells. The effect of cyclophosphatation, thereby relaxing vascular smooth muscle. Isosorbide mononitrate expands blood vessels by relaxing vascular smooth muscles, and can dilate peripheral arteries and veins. Expansion of veins increases venous volume and reduces blood return to the heart, thereby reducing ventricular end-diastolic pressure and volume (preload); dilation of arteries and arterioles reduces system vascular resistance (afterload), reducing myocardial work; reducing cardiac preload , Thereby reducing myocardial oxygen consumption. Moreover, when the coronary arteries are partially blocked due to arteriosclerosis, isosorbide mononitrate can selectively expand large coronary arteries, promote the redistribution of myocardial blood flow, increase coronary perfusion, and nitrates can also expand coronary stenosis Location, and relieve coronary artery spasm. Isosorbide mononitrate exerts anti-myocardial ischemia effects through the above effects.

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