Compound Diphenoxylate Hydrochloride Tablets Reference Listed Drug

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Name	Compound Diphenoxylate Hydrochloride Tablets
Trade name	Lomotil
Specifications	Diphenoxylate hydrochloride 2.5mg, atropine sulfate 25μg
Dosage form	tablet
Licensee	GD SEARLE LLC
Remarks	The Orange Book of the United States, the United States market name: diphenoxylate hydrochloride and atropine sulfate tablets

【Indications】 Used for acute and chronic functional diarrhea and chronic enteritis. 【Taboo】 Patients with severe ulcerative colitis may develop toxic megacolon and should be disabled; Patients with liver cirrhosis and jaundice should be used with caution because they can induce hepatic encephalopathy. 【Precautions】 This product can cause dependence when used for a long time, but it is obviously weaker than opiates. Patients with liver disease and patients who are taking addictive drugs should use it with caution; Only use constant short-term treatment to avoid dependence; Patients with early diarrhea and abdominal distension should be used with caution; Acute diarrhea caused by Shigella, Salmonella and certain E. coli bacteria often invade the mucosa of the intestinal wall. This product reduces intestinal motility, delays the elimination of pathogens, and prolongs the course of the disease. Therefore, this product cannot be used as a basic treatment for bacterial diarrhea. . [Medicine for pregnant and lactating women] It has teratogenic effects and is forbidden for pregnant women; breastfeeding women should also use it with caution.

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