Torasemide Tablets Reference Listed Drug

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Name	Torasemide Tablets
Trade name	DEMADEX
Specifications	5mg；10mg；20mg
Dosage form	tablet
Licensee	MYLAN SPECIALTY LP
Remarks	American Orange Book (name of collection: torsemide tablets; products of Meda Pharmaceuticals Inc. as licensee)

This product mainly acts on the thick ascending branch of the medullary loop and inhibits the Na+/K+/2Cl- transport system. Clinical pharmacology studies have also confirmed that this is the site of action of this product in the human body and has no effect on other parts of the kidney. Therefore, the degree of correlation between the diuretic effect of this product and the excretion rate of the drug in the urine is higher than the concentration in the blood. Torasemide can increase the excretion of sodium, chloride and water in the urine, but does not significantly change the glomerular filtration rate, renal blood flow and acid-base balance.

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