Pamidronate Disodium API

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Name	Pamidronate Disodium
Chinese name	帕米膦酸二钠
Cas Number	109552-15-0
Source	Italy
Qualifications	-/USDMF/-/-

 

Bone metastases are the most common clinical complication in malignant tumors. According to statistics, about 20% -70% of patients with malignant tumors will have bone metastases. The occurrence of bone metastases suggests that tumor progression has reached the advanced stage and the pathological changes caused by bone metastases complications such as fractures have caused great pain to patients. The main clinical symptoms include pain in the transfer site, symptoms of nerve compression, pathological fractures, nerve root damage and spinal cord compression. Therefore, it is very important to relieve the bone pain of patients with bone metastasis and to suppress the occurrence and development of metastasis. Bisphosphonates are the internationally recognized drugs for the treatment of bone metastases. Studies have shown that they can inhibit bone re-sorption, induce osteoclast death, and enhance the activity of osteoclasts caused by the release of various stimulating factors, and relieve the pain of patients with bone pain symptom. Bone metastases is a malignant tumor of other organs transferred to the bone of the tumor, is one of the common clinical tumor complications. Pamidronate disodium is the second generation of bisphosphonates, studies have shown that pamidronate disodium for cancer-related hypercalcemia and malignant tumors caused by bone pain have a good effect in the treatment of diseases associated with abnormally increased osteoclast activity, and osteolysis caused by advanced tumor bone metastases.

 

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