Lercanidipine Hydrochloride API

Name	Lercanidipine Hydrochloride
Chinese name	盐酸乐卡地平
Cas Number	132866-11-6
Source	India
Qualifications	-/-/-/-/-

Lercanidipine is a third-generation dihydropyridine calcium antagonist, which reversibly blocks the Ca2+ inflow of the L-type calcium channel of the vascular smooth muscle cell membrane, dilates the peripheral blood vessels and lowers blood pressure. It is a long-acting time and high vascular selectivity. The highly lipophilic dihydropyridine calcium channel blocker (CCB). The affinity of lercanidipine to vascular smooth muscle is significantly higher than that of other dihydropyridine CCBs, which suggests that lercanidipine has a lower negative inotropic effect, which makes lercanidipine a higher cardiac safety; its peripheral edema The incidence is lower than that of amlodipine and nifedipine first-generation CCB, and the patients are well tolerated. In addition, lercanidipine also has the effects of anti-atherosclerosis and end-organ protection, and does not interfere with the normal cardiac excitability and conductivity of hypertensive patients at the treatment dose.

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