Cyclophosphamide API

* Please be kindly noted products are offered for R&D purpose only. Not for human or veterinary use.

 

Name	Cyclophosphamide
Chinese name	环磷酰胺
Cas Number	50-18-0
Source	India
Qualifications	-/-/-/-

 

Cyclophosphamide is the most versatile and useful of nitrogen mustards. Preclinical testing showed it to have a favorable therapeutic index and to possess the broadest spectrum of antitumor activity of all alkylating agents. As with the other nitrogen mustards, cyclophosphamide administration results in the formation of cross-links within DNA due to a reaction of the two chloroethyl moieties of cyclophosphamide with adjacent nucleotide bases. Cyclophosphamide must be activated metabolically by microsomal enzymes of the cytochrome P450 system before ionization of the chloride atoms and formation of the cyclic ethylenimmonium ion can occur. The metabolites phosphoramide mustard and acrolein are thought to be the ultimate active cytotoxic moiety derived from cyclophosphamide.

 

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