Dexrazoxane API

Name	Dexrazoxane
Chinese Name	右雷佐生
CAS. No.	24584-09-06
Molecular Formula	C11H16N4O4
Molecular Weight	268.27 g/mol
Source	India
Qualifications	USDMF/-/-/-/-

 

Dexrazoxane was developed by Chiron Corporation of the United States, first launched in Italy in 1992, and approved by FDA in July 1995. It was subsequently launched in Europe, Asia, Africa and other countries. Dexrazoxane is clinically indicated for the prevention of anthracycline-induced cardiotoxicity. Dexrazoxane is the d-isomer of racemic razoxane and a lipophilic derivative of the chelating agent ethylenediaminetetraacetic acid, which can quickly penetrate the cell membrane and reduce the cardiotoxicity of anthracycline antitumor antibiotics such as doxorubicin, Dexrazoxane is hydrolyzed into TCRE-198 in the cell and then chelated with intracellular iron, reducing the complexity of ferric ion and doxorubicin and other anthracycline antineoplastic drugs, preventing the formation of free radicals and take effect.

 

Dexrazoxane is currently the only clinically approved drug for the prevention of cardiotoxicity of anthracyclines. Clinical trials in European and American countries have shown that this drug is expected to become a standard compatible drug for anthracycline antineoplastic drugs. Although dexrazoxane is currently mainly used to prevent anthracycline-induced cardiotoxicity, its potential in regulating topoisomerase II activity and cellular iron metabolism will be used in cancer treatment, immunology, infectious diseases, etc. in the future. Aspects of application will likely become the focus.

 

 

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