Alfacalcidol API

Name	Alfacalcidol
Chinese name	阿法骨化醇
Cas Number	41294-56-8
Source	India
Qualifications	/-/-/-/-

Alfacalcidol can increase the reabsorption of calcium in the small intestine and renal tubules, inhibit parathyroid hyperplasia, reduce the synthesis and release of parathyroid hormone, and inhibit bone absorption; increase transforming growth factor-B (TGF-B) and insulin-like Growth factor-I (1GF-I) synthesis promotes the synthesis of collagen and bone matrix protein, enhances muscle strength, and increases neuromuscular coordination. Studies have shown that in increasing calcium absorption, alfacalcidol (0.5μg) is more advantageous than ordinary vitamin D2 (500-1000 IU) in increasing calcium absorption; in increasing bone density, alfacalcidol is more common Vitamin D significantly increases the bone mineral density of the lumbar spine; in terms of reducing the incidence of falls and fractures, alfacalcidol significantly reduces the incidence of falls, new vertebral fractures and non-vertebral fractures compared with ordinary vitamin D. A number of studies have shown that compared with calcitriol, treatment with alfacalcidol is less likely to cause hypercalciuria. In 2017, terminal alfacalcidol sales in public medical institutions in China exceeded 900 million yuan, of which capsules accounted for 86.13% and tablets accounted for 13.68%. The population of osteoporosis patients in China is huge and getting younger, and the market size of alfacalcidol is steadily increasing.

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