Hydroxycobalamin Hydrochloride API

Name	Hydroxycobalamin Hydrochloride
Chinese name	盐酸羟钴胺
Cas Number	58288-50-9
Source	India
Qualifications	-/-/-/-/-

Hydroxycobalamin hydrochloride is a safe, non-toxic, rapid-acting new cyanide antidote. In view of the special nature of the treatment of cyanide poisoning, the US FDA approved the use of hydroxycobalamin on December 15, 2006 through the priority review channel. Known or suspected of cyanide poisoning treatment, hydroxycobalamin hydrochloride became the first emergency medicine approved for cyanide poisoning in the United States. Hydroxycobalamin hydrochloride can quickly complex with the cyanide ion in the body, and the cyanide ion replaces the hydroxyl group coordinated by the cobalt ion in the hydroxycobalamin molecule to form a stable and non-toxic product cyanocobalamin (ie VB12), which passes through the urine Clear. Compared with other cyanide antidote currently used clinically, the most prominent advantages of hydroxycobalamin hydrochloride are: (1) It can be used for the treatment of suspected cyanide poisoning, so it is especially suitable for out-of-hospital first aid at the accident site. (2) The detoxification process does not require the participation of hemoglobin, so it does not affect the oxygen-carrying capacity of the blood in the patient's body, and can be used for emergency treatment of cyanide poisoning under the condition of hypoxia. Studies have also found that hydroxycobalamin hydrochloride is better than adenosine coenzyme B12 in improving symptoms and signs of diabetic neuropathy. Hydroxycobalamin hydrochloride is not only effective in treating cyanide poisoning, but also has a wide range of indications and has a large market development space.

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