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CAS:25332-39-2
Source:India
Qualifications:USDMF/-/-/-/-
Name | Trazodone hydrochloride |
---|---|
Chinese name | 盐酸曲唑酮 |
Cas Number | 25332-39-2 |
Source | India |
Qualifications | USDMF/-/-/-/- |
Trazodone hydrochloride is a serotonin (5-HT) receptor blocker and reuptake inhibitor. It was first marketed in Italy in 1972 and is now used in the treatment of mild and moderate depression in many countries. Trazodone hydrochloride is an atypical tetracyclic antidepressant. It can block the reabsorption of 5‑HT (serotonin), and its metabolites can antagonize 5‑HT, thereby producing antidepressant effects. . Trazodone hydrochloride can selectively block H1 receptors and α1 adrenal receptors, thereby producing obvious sedative and hypnotic effects. Studies have shown that the total effective rate of trazodone hydrochloride in the treatment of depression with sleep disorders is higher than that of clonazepam, and the PSQI score after treatment is better. It has also been clinically proven that the antidepressant and anxiolytic properties of trazodone hydrochloride can be used to treat withdrawal symptoms from cocaine, benzodiazepines and alcohol. In addition, trazodone hydrochloride has obvious effects on improving sleep disorders. In recent years, the sales of trazodone hydrochloride in public hospitals in Chinese cities have been steadily rising, breaking through the 100 million yuan mark in 2015, which also reflects the increasing sense of identity of trazodone by patients and doctors. The prevalence of depression in my country reached 2.1%. In 2019, the sales of terminal antidepressant drugs in public medical institutions in China exceeded 9 billion yuan, a year-on-year increase of over 10%.
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