Azelastine Hydrochloride API

Name	Azelastine Hydrochloride
Chinese name	盐酸氮卓斯汀
Cas Number	79307-93-0
Source	Europe
Qualifications	/CEP/-/-/-

Azelastine hydrochloride nasal spray is a new structure of 2,3 phthalazinone derivative. It is a potential long-acting anti-allergic compound and has the characteristics of an H1 receptor antagonist. In addition to antagonizing histamine, azelastine hydrochloride also has a variety of anti-allergic effects. Azelastine hydrochloride inhibits and directly antagonizes the production and release of leukotrienes and histamines that cause allergic reactions. , Can inhibit experimental wheezing, nasal allergies and urticaria, etc., with strong and lasting effects. Related reports pointed out that azelastine can inhibit the activation of inflammatory cells and the release of different mediators, reduce the migration of eosinophils, significantly reduce the expression of ICAM-1, and reduce serum eosinophilic cation (ECP) levels. There are also reports in the literature that azelastine can enhance the anti-inflammatory effect of budesonide. Since 2016, the sales scale of terminal respiratory nasal preparations for public hospitals in key cities in China has been around 200 million yuan. In recent years, there has been a rapid growth trend. Sales in the first three quarters of 2018 have been close to 180 million yuan.

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