Bilastine API

Name	Bilastine
Chinese name	比拉斯汀
Cas Number	202189-78-4
Source	India
Qualifications	USDMF/-/-/-/-

Bilastine is a second-generation histamine H1 receptor antagonist developed by FAES Pharmaceuticals in Spain. It is a new second-generation antihistamine with a different chemical structure from existing antihistamines. Compared with H1 antihistamines, it has better pharmacological characteristics. Compared with H1 receptor antagonists cetirizine and fexofenadine, bilastine H1 receptor has a higher affinity; compared with other 30 related receptors, bilastine has a higher affinity for histamine H1 The selectivity of the body is higher. In addition, bilastine not only has a stronger inhibitory effect on tracheal and ileal contraction caused by H1 receptor activation than cetirizine, but also has a better inhibitory effect on the allergic contraction of ileal smooth muscle caused by ovalbumin than cetirizine. And fexofenadine. In improving the symptoms of urticaria and the quality of life of patients, 20 mg/d bilastine is at least as effective as 5 mg/d levocetirizine, and has a smaller effect on the central nervous system than cetirizine. Bilastine hardly penetrates the blood-brain barrier. The therapeutic dose of bilastine does not interact with ethanol, nor does it interact with lorazepam. Due to its pharmacological characteristics and safety, bilastine will provide a new medication option for urticaria and other allergic skin diseases. In 2018, Bilastine's global sales were 386 million yuan.

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