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CAS:72956-09-3
Source:India
Qualifications:/-/-/-/-
Name | Carvedilol |
---|---|
Chinese name | 卡维地洛 |
Cas Number | 72956-09-3 |
Source | India |
Qualifications | /-/-/-/- |
Carvedilol is a third-generation β-blocker, developed and marketed by Roche. In 1995, the US FDA approved the drug for the treatment of chronic congestive heart failure. It has been widely used in various countries around the world in 1996. In addition to blocking adrenaline β1 and β2 receptors, carvedilol also blocks adrenaline α1 receptors and blocks calcium, sodium and potassium channels, inhibits smooth muscle cell proliferation, has anti-inflammatory, antioxidant, and inhibitory effects. The vasoconstrictor effect of prostaglandin F1a. Clinical studies have proved that carvedilol can significantly reduce the morbidity and mortality of heart failure, and at the same time prevent the occurrence of cell apoptosis, which is unmatched by traditional β-blockers. Compared with the similar drug metoprolol, carvedilol has a higher total effective rate and aggravated heart failure and a lower number of cases of atrioventricular block (AVB). Compared with propranolol, carvedilol has little effect on the heart rate of patients with resting or exercise hypertension. In 2018, the sales of beta-blockers in sample hospitals were 1.089 billion yuan, a year-on-year increase of 6.24%
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