Metoprolol Succinate API

Name	Metoprolol Succinate
Chinese name	琥珀酸美托洛尔
Cas Number	98418-47-4
Source	Europe
Qualifications	USDMF/-/-/-/-

Metoprolol succinate was approved by the US FDA in 1992 for the treatment of hypertension and angina pectoris. It is currently the most widely used beta-blocker drug in the world. Due to the solubility problem of metoprolol tartrate, AstraZeneca launched Betaloc ZOK, or metoprolol succinate sustained-release tablets. The solubility of metoprolol succinate in water at 37°C is significantly lower than that of metoprolol tartrate, which significantly delays the dissolution rate, achieves a slow and long-lasting release of metoprolol, and improves medication compliance to a certain extent. It reduces adverse reactions. Metoprolol succinate can attenuate the effects of catecholamines related to physical and psychological load, and reduce heart rate, cardiac output and blood pressure. At the same time, the contraction effect of metoprolol succinate on bronchial smooth muscle is weaker than that of non-selective β-receptor blockers. This feature allows it to be used in combination with β2 receptor agonists to treat combined bronchial asthma or other obvious obstructions. Patients with lung disease.

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