Palonosetron Hydrochloride API

Name	Palonosetron Hydrochloride
Chinese name	盐酸帕洛诺司琼
Cas Number	135729-62-3
Source	India
Qualifications	USDMF/-/-/-/-

Palonosetron is a selective serotonin 3 receptor (5-HT3) antagonist developed by Helsinn Healthcare. It was launched in the United States in September 2003. Similar varieties include ondansetron, granisetron, tropisetron, dorasetron, azasetron, etc., and these five occupy 95% of the antiemetic market. Compared with previous 5-HT3 receptor antagonists, Palonosetron hydrochloride has a stronger binding force to 5-HT3 receptors, and its receptor binding activity is dozens to hundreds of times stronger than other varieties. Longer half-life (more than 40 hours). It is not only effective for patients who do not respond to ondansetron hydrochloride, granisetron hydrochloride, or tropisetron hydrochloride, but it is also the only 5-HT3 receptor antagonist approved by the US FDA for the treatment of delayed vomiting caused by chemotherapy. Palonosetron injection has become the leader of its kind and is a promising antiemetic drug for cancer chemotherapy.

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