Acetazolamide API

Name	Acetazolamide
Chinese name	乙酰唑胺
Cas Number	59-66-5
Source	India
Qualifications	USDMF/CEP/-/-/-

Acetazolamide is one of the first-generation oral carbonic anhydrase inhibitors for the treatment of cardiogenic edema and glaucoma. Acetazolamide is mainly used clinically to reduce intraocular pressure, can inhibit the activity of ciliary epithelial carbonic anhydrase, thereby reducing the production of aqueous humor (50% to 60%), reducing intraocular pressure, and suitable for the treatment of various types of glaucoma , Has always played an irreplaceable role in clinical practice. In the case of volume overload and diuretic resistance, acetazolamide is more effective than thiazide diuretics and mineralocorticoid receptor antagonists. In recent years, studies have found that acetazolamide has a broad-spectrum inhibitory effect on carbonic anhydrase in human red blood cells, gastric mucosa, renal parenchyma, pancreas, central nervous system and many other tissues, which makes the intracellular biochemical reaction of CO2+H2O≒(H+)+ (HCO3‑) The positive pathway is blocked, thereby correcting many pathological disorders of biochemical metabolism, thus expanding a series of new clinical uses. At present, acetazolamide has in-depth application research in acute altitude sickness, chronic altitude sickness, cerebrovascular disease, tumor, refractory hiccups, epilepsy, metabolic bone disease, oxygen convulsions, etc.

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