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CAS:115256-11-6
Source:India
Qualifications:USDMF/-/-/-/-
Name | Dofelite/Dofelite |
---|---|
Chinese name | 多非利特/多菲利特 |
Cas Number | 115256-11-6 |
Source | India |
Qualifications | USDMF/-/-/-/- |
Dofetilide is an oral antiarrhythmic drug for atrial fibrillation developed by Pfizer in the United States. It has a high effect on reversing sinus rhythm. It was first listed in the United States in May 2000 and is a recommended drug in relevant US guidelines. This product is an anti-arrhythmic drug with strong action and good selectivity, and has the advantages of significant curative effect and relatively small adverse reactions. Dofetilide is a methanesulfonamide derivative similar in structure to the antiarrhythmic drug sotalol. Its pharmacological mechanism of action is to increase action potential duration (QT interval) by inhibiting rapid potassium current (Ikr) The effect of class III antiarrhythmic drugs can be used to treat and prevent atrial arrhythmia and paroxysmal supraventricular tachycardia. It is also better than other anti-arrhythmic drugs in the conversion of recent atrial fibrillation and atrial flutter Arrhythmic drugs can be used to prevent the occurrence of ventricular tachycardia and relieve the condition of patients with heart failure. In the global market, the scale of the Dofelt market continues to grow, with market sales exceeding US$120 million in 2018. Dofeilide was included in the first batch of encouraged generic drugs catalogues in China in 2019.
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