Brimonidine Tartrate API

Name	Brimonidine tartrate
Chinese name	酒石酸溴莫尼定
Cas Number	70359-46-5
Source	India
Qualifications	USDMF/-/-/-/-

Brimonidine tartrate, a selective α2-adrenergic agonist, has been used as a single intraocular pressure (IOP) reduction in the treatment of glaucoma and ocular hypertension (OHT) since it was approved in 1996. Therapy or adjuvant therapy. Brimonidine tartrate is highly selective for α2-adrenergic receptors, and has an obvious and long-lasting effect on lowering intraocular pressure, as well as potential neuroprotective effects. It has a dual mechanism of action, which is to reduce intraocular pressure by reducing the production of aqueous humor and increasing scleral uveolar outflow. The selectivity of brimonidine tartrate for α2-receptors is 7 to 12 times higher than that of clonidine and 23 to 32 times higher than that of apraclonidine. In 2017, the U.S. FDA approved brimonidine tartrate eye drops as the first and only over-the-counter (OTC) eye drops developed for low-dose brimonidine tartrate for the treatment of red and swollen eyes. Compared with the non-selective eye drops that are frequently used clinically to relieve redness and swelling, low-dose brimonidine tartrate selectively constricts the intraocular veins and increases the oxygen supply to the surrounding tissues, thereby reducing side effects (resulting in drug resistance and even increasing redness and swelling) Potential risks. In the past three years, the usage of brimonidine tartrate eye drops has consistently ranked among the top two in China for lowering intraocular pressure. Brinzolamide Brimonidine Eye Drops were approved by the FDA in April 2013 and NMPA approved in July 2019. Alcon claims that this drug is the only drug that does not contain beta receptor blockers. A fixed-dose glaucoma compound drug.

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