Tibolone API

Name	Tibolone
Chinese name	替勃龙
Cas Number	5630-53-5
Source	Italy
Qualifications	-/CEP/-/-/-

Tibolone is a tissue selective modulator of estrogen activity (STEARs), which is a synthetic steroid hormone. Tibolone itself has very weak hormonal activity, which mainly depends on the activity of local enzymes in the tissue and the specific metabolic mechanism of the tissue. It exerts different effects in different tissues, but it avoids the need for estrogen stimulation in the endometrium and breast. The part plays the role of estrogen. Compared with traditional hormone replacement therapy (tamoxifen, etc.), women taking tibolone have a lower incidence of breast adverse events. Compared with conventional treatment, tibolone has a significant clinical effect in treating breast hyperplasia in postmenopausal women without affecting estrogen and lipid metabolism, and has better safety. At the same time, trials have proved that Tibolone can effectively reduce the risk of fracture, breast cancer, and even colon cancer in women over 60 years of age with osteoporosis. In 2017, the estrogen drug market in public hospitals in key cities in China was 140 million yuan, a year-on-year increase of 12.33%.

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