Tasimelteon API

Name	Tasimelteon
Chinese Name	他司美琼
CAS. No.	-
Molecular Formula	-
Molecular Weight	-
Source	Europe
Qualifications	-/-/-/-/-

 

 

Tasimetron is a small molecule melatonin receptor agonist developed by Vanda Pharma in Maryland, USA. In January 2010, the FDA granted it orphan drug qualification for the treatment of non-24 patients with complete blindness. Hour sleep disorder, which was approved by the US FDA in January 2014, is the first mental disorder drug approved by the FDA for the treatment of this disease. Tasimelteon is a selective MT1 and MT2 receptor agonist, which can simulate melatonin to activate the receptors in the suprachiasmatic nucleus, and can promote the organism to enter the night sleep state, thereby regulating the non-24-hour wakefulness disorder. The assessment results of tasimeltron on the Non-24 Clinical Response Scale (non-non-24CRS) and the Clinical Global Impression of Change (CGI-C) were compared with those of placebo, and the nighttime sleep time of patients taking tasimeltron increased (increased by 28 minutes compared with the placebo group) and decreased daytime sleepiness (decreased by 27 minutes compared with the placebo group). Preclinical studies have shown that tasimelteon has the properties of regulating circadian rhythm similar to melanin, and has less vasoconstriction effect. Tasimelon has a price point of small dosage, strong curative effect and good tolerance, and has a good application prospect.

 

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