Crisaborole API

Name	Crisaborole
Chinese Name	克立硼罗
CAS. No.	906673-24-3
Molecular Formula	C14H10BNO3
Molecular Weight	251.05 g/mol
Source	/
Qualifications	-/-/-/-/-

 

 

Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by the USFDA for the treatment of mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin and rapid clearance to limit systemic circulation.

 

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