Efinaconazole API

Name	Efinaconazole
Chinese Name	艾氟康唑
CAS. No.	164650-44-6
Molecular Formula	C18H22F2N4O
Molecular Weight	348.39 g/mol
Source	/
Qualifications	-/-/-/-/-

 

 

In October 2013, Efinaconazole, also known as KP-103, was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, Efinaconazole acts by disrupting fungal cell membranes through the inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes and Trichophyton rubrum, as well as against Candida and Malassezia species. Unlike other antifungal agents, Efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by the reaction of an epoxide intermediate with 4-methylenepiperidine.

 

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