Oxaliplatin API

Name	Oxaliplatin
Chinese name	奥沙利铂
Cas Number	63121-00-6
Source	India/Europe
Qualifications	USDMF/-/-/-/-

The original research was Debiopharm, which was listed in the United States in 2002 and in China and Japan in 2004. Oxaliplatin (L-OHP), as the third-generation platinum anti-tumor drug, is mainly used in clinical treatment for colorectal cancer, breast cancer, pancreatic cancer, lung cancer, and ovarian cancer. Its mechanism of action takes DNA as the target site, and platinum ions form cross-links with DNA strands, thereby blocking its replication and transcription. Compared with cisplatin (DDP), its DNA binding kinetics characteristics are obviously different. The DNA binding kinetics characteristics of cisplatin are biphasic. It takes 15 minutes for fast-phase binding and 4-8 hours for slow-phase binding. Completely bind to DNA within 15 minutes. Platinum drugs have high anti-tumor activity. Many basic and clinical trials have fully proved that they are effective when used alone or in combination with other drugs. Therefore, they are widely used in the treatment of ovarian cancer, colorectal cancer and lung cancer and other solid tumors. Very important basic chemotherapy drugs.

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