Bedaquinoline Fumarate API

Name	Bedaquinoline fumarate
Chinese name	富马酸贝达喹啉
Cas Number	843663-66-1
Source	India
Qualifications	-/-/-/-/-

Bedaquinoline is a diarylquinoline anti-mycobacterial drug that inhibits the mycobacterial ATP (adenosine triphosphate) synthase. The enzyme is necessary for the energy production of Mycobacterium tuberculosis. The subunit c that binds the enzyme plays a role. The expert consensus on the clinical application of the new anti-tuberculosis drug bedaquiline (2018) pointed out that bedaquiline is the first new anti-tuberculosis drug to be marketed in the past 50 years. It has a unique mechanism of action, strong anti-Mycobacterium tuberculosis (MTB) activity, The clinical effect is good. In December 2012, the U.S. Food and Drug Administration accelerated the approval of bedaquiline for the treatment of adult MDR-TB. In June 2013, the World Health Organization issued the "Guidelines for the Interim Strategy of Bedaquiline Treatment of MDR-TB". In 2017, the World Health Organization updated the "Guidelines for Bedaquiline Treatment of MDR-TB" again. As the patent period approaches, it is predicted that Bedaquinoline will be a hot spot in the field of anti-tuberculosis in the next two years.

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