Dapsone API

Name	Dapsone
Chinese name	氨苯砜
Cas Number	80-08-0
Source	India
Qualifications	USDMF/-/-/-/-

Dapsone is a sulfone antibacterial drug, which has a strong antibacterial effect on leprosy bacillus. Its preparation has been widely used in the treatment of leprosy. Dapsone is the drug of choice for the treatment of leprosy. It acts on the dihydrofolate synthase (DHPs) of bacteria, interferes with the synthesis of folic acid, and affects the synthesis of protein by the bacteria. In addition, dapsone also has an anti-inflammatory effect. It has a significant scavenging effect on toxic oxygen free radicals and other substances produced by neutrophils after being stimulated. It can also inhibit the aggregation and activation of neutrophils, and reduce The release of inflammatory mediators, thereby reducing damage to the body. Studies have shown that the plasma concentration achieved by oral administration of 100 mg dapsone is 500-600 times the minimum inhibitory concentration required to inhibit Mycobacterium leprae. In recent years, studies have found that dapsone can also be used for other infectious diseases, inflammatory skin diseases, autoimmune bullous disease, urticaria, etc., with a wide range of indications. Global sales of dapsone in 2016 was US$380 million, an increase of more than 20% over the previous year.

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