Azathioprine API

Name	Azathioprine
Chinese name	硫唑嘌呤
Cas Number	446-86-6
Source	India
Qualifications	USDMF/-/-/-/-

Azathioprine has been used as an immunosuppressant for more than 40 years and is widely used in clinical practice. It is approved by the US Food and Drug Administration (FDA) for the treatment of active rheumatoid arthritis. Azathioprine is also approved as an adjuvant therapy to prevent renal transplant rejection, including it is also recognized in dermatology. Azathioprine can produce alkylation to block SH group, inhibit nucleic acid biosynthesis, prevent cell proliferation, and cause DNA damage, reduce DNA and RNA in thymus and spleen, and affect DNA, RNA, and The synthesis of protein mainly inhibits T-lymphocytes and affects immunity, so it can inhibit delayed allergic reactions and rejection of organ transplants. Some research conclusions indicate that the treatment of azathioprine in active patients with moderate generalized colitis who failed first-line treatment and hormone therapy can achieve the expected curative effect and is worthy of promotion. The Pharmaceutical Comprehensive Database (PDB) shows that the azathioprine market is volatile in the global market. In 2018, the global sales of azathioprine exceeded US$190 million.

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