Fosfomycin Tromethamine API

Name	Fosfomycin tromethamine
Chinese name	磷霉素氨丁三醇
Cas Number	78964-85-9
Source	Europe
Qualifications	USDMF/-/-/-/-

Fosfomycin tromethamine is an antibiotic, a tromethamine salt of fosfomycin. The European Urological Association upgraded it to the first-line first-line empirical medicine for simple cystitis in the 2010 edition of the "Guidelines for Urinary System Infections" . Fosfomycin tromethamine is a milder and more effective antibacterial drug, which can directly prevent the action of pyruvate transferase, which is necessary for bacterial cell wall synthesis. Fosfomycin tromethamine is a broad-spectrum antibiotic, and its oral absorption and bioavailability are significantly improved compared with fosfomycin tromethamine calcium and sodium salts. Healthy people take fosfomycin tromethamine at a dose of 50mg/kg, the plasma concentration reaches its peak 2 hours after 35.6mg/L, which is 4.4 times that of fosfomycin calcium, with a half-life of 3 hours. When fosfomycin tromethamine and penicillins, cephalosporins, aminoglycosides and other antibiotics are used in combination, they have a synergistic strengthening effect and delay the development of drug resistance. According to estimates of sales in Europe, China has a market capacity of 50 million bags, a preparation market of 5 billion yuan, and an API market of 150 million yuan.

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