Decitabine API

Name	Decitabine
Chinese name	地西他滨
Cas Number	2353-33-5
Source	India
Qualifications	USDMF/-/-/-/-

Decitabine is a 2'-deoxycytidine analog, approved by the European EMEA and the US Food and Drug Administration in 2006 for the treatment of myelodysplastic syndrome. Decitabine is recommended as the priority drug for MDS by the guidelines of the Comprehensive Cancer Network of the United States due to its unique mechanism of directly acting on DNA. In view of the current status of MDS treatment in my country, in September 2008, the State Food and Drug Administration (SFDA) approved the direct marketing of Decitabine from clinical trials, and the drug became the only drug exempted from clinical approval by SFDA since 2005. After phosphorylation, decitabine is directly incorporated into DNA methyltransferase to methylate DNA, leading to cell differentiation or apoptosis, thereby exerting anti-tumor effects. A retrospective study comparing the efficacy of patients with myelodysplastic syndromes showed that among patients with high-risk karyotypes, the complete remission rate of the decitabine group was significantly higher than that of the CHG regimen, and the overall survival of patients receiving decitabine treatment The time has been significantly extended. The United States MD Anderson Cancer Center Kadia et al. reported that the alternate application of cladribine combined with low-dose cytarabine and decitabine is a safe and effective program for the first-line treatment of newly diagnosed acute myeloid leukemia (AML) patients. Decitabine has achieved remarkable sales in major domestic hospitals in China in recent years, especially the growth rate after 2016 has increased significantly. In 2018, sales exceeded 140 million yuan, a year-on-year increase of 51.66%.

Hot Tags: decitabine api, China, suppliers, manufacturers, factory, customized, price, pricelist, in stock, Edoxaban API, Pazopanib Hydrochloride Pazopanib API, Oseltamivir Phosphate API, Tavaborol API, Ulipristal Acetate API, Salmeterol Xinafoate API

• Previous: Vidagliptin API
• Next: Foscarnet Sodium API