Methimazole API

Name	Methimazole
Chinese name	甲巯咪唑
Cas Number	60-56-0
Source	Europe
Qualifications	-/-/-/-/-

Methimazole (also known as tapazole, methylthioimidazole, metthiazole, mecarzolil) can inhibit the synthesis of thyroid hormones and is a representative drug for the clinical treatment of hyperthyroidism. The mechanism of methimazole is by inhibiting the activity of peroxidase in the thyroid, hindering the oxidation of iodide and coupling of tyrosine in the thyroid, and hindering the synthesis of thyroxine (T4) and triiodothyronine (T3) , Play a role in the treatment of hyperthyroidism. In 2011, ATA and AACE in the United States clearly recommended methimazole as the drug of choice for the treatment of hyperthyroidism in the guidelines for the diagnosis and treatment of hyperthyroidism. Clinical studies on the treatment of hyperthyroidism have shown that the serum FT3, FT3 and TRAB levels of patients treated with methimazole were significantly lower than those treated with propylthiouracil, and the serum TSH levels were significantly higher. The indicator is closer to the normal value. Due to its good effect and relative safety, methimazole has always been used as the first-line drug for the treatment of hyperthyroidism.

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